The Endocannabinoid System

Wikipedia's Extremely Easy To Understand Description, not.

The endocannabinoid system (ECS) is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. Known as “the body’s own cannabinoid system”,[1] the ECS is involved in a variety of physiological processes includingappetite, pain-sensation, mood, and memory, and in mediating the psychoactive effects of cannabis.

Two primary endocannabinoid receptors have been identified: CB1, first cloned in 1990; and CB2, cloned in 1993. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), Anandamide, as well as its mimeticphytocannabinoid, THC. One other main endocannabinoid is 2-Arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD. 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management.[1][2][3]

Real Questions asked by Real People

How Many Cannabinoid Receptors Are There In The Human Body?

Researchers have identified two cannabinoid receptors: CB1, predominantly present in the nervous system, connective tissues, gonads, glands, and organs; and CB2, predominantly found in the immune system and its associated structures. Many tissues contain both CB1 and CB2 receptors, each linked to a different action.

Are Endocannabinoids Neurotransmitters?

The primary neuronal subtype of this receptor, known as CB1, is widely distributed in the mammalian brain and is expressed in presynaptic terminals, where it can inhibit neurotransmitter release. The endocannabinoid system is thus well suited for rapid retrograde signaling across activated synapses.

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Endocannibinoid System

The Endocannabinoid System Explained